Day 1 :
Keynote Forum
Reyhaneh Varshochian
Assistant Professor in Department of Pharmaceutics and Pharmaceutical Nanotechnology
Keynote: Thermosensitive in situ forming gel containing bevacizumab loaded nanoparticles for choroidal neovascularization treatment
Time : 9:30-10:30
Biography:
Reyhaneh is an assistant professor in Department of Pharmaceutics and Pharmaceutical Nanotechnology and a highly motivated researcher in the field of Nano medicine and biomaterials with a 7-year experience of working in Research and Development (R&D) of pharmaceutical industries. Her postdoctoral research was focused on preparation and in vivo evaluation of novel drug delivery system intended for age-related macular degeneration (AMD) treatment, and she has an 8-year background of teaching as a lecturer.
Abstract:
Choroidal neovascularization (CNV) is considered as the leading cause of vision loss in different posterior segment ocular diseases such as proliferative diabetic retinopathy, retinal vein occlusions, retinopathy of prematurity, and age-related macular degeneration (AMD). Today, the most effective treatments of CNV are the ones applied through injections; however, short half-life and fast clearance of drugs, e.g. bevacizumab, in vitreous leading to the need for multiple injections that is the main drawback of these treatments. To address this problem administration of controlled drug delivery systems such as particulate carriers have been suggested. Moreover, the thermosensitive in situ forming gels are good candidates for sustaining the drug release and can improve the drug- releasing features of nanoparticles. Following to our previous studies, here a novel nano drug delivery system was formulated. Accordingly, bevacizumab loaded polymeric nanoparticles with the mean particle size of 185 nm were prepared and embedded in the termosensitive three-block copolymer and the in vitro characteristics was evaluated. During the in vivo investigations a single dose of formulation was intravitreally injected to rabbits. The vitreous concentration of the drug was assayed in different time intervals using ELISA method and intraocular pharmacokinetic parameters were determined. The results revealed around 4 times higher mean residence time of bevacizumab in rabbit treated by our formulation in comparison to the controls which indicated the promising potentials of designed formulation as a novel ocular drug delivery system.
- Nanoscience and Nanotechnology | Nano Pharmaceutical Chemistry | Nanochemistry Applications | Organic Materials in Nanochemistry
Location: Paris, France
Session Introduction
Umer Aziz
Ghulam Ishaq Khan Institute of Engineering Sciences and Technology, Pakistan
Title: Hierarchically porous manganese based metal-organic-framework for potential battery-supercapacitor applications
Biography:
Umer Aziz is graduated from Islamia College University, Peshawar with a field of interest in Physics and material science. He is currently expertise in Applied Physics at Ghulam Ishaq Khan Institute, Pakistan. His past research has focused on Lead-free piezoelectric ceramics and currently studying different nanomaterials for hybrid supercapacitors applications. He is currently interested in perusing his PhD in the area of batteries and supercapacitors. After completion of the program, he aspires to work as a researcher in the industry.Umer Aziz is graduated from Islamia College University, Peshawar with a field of interest in Physics and material science. He is currently expertise in Applied Physics at Ghulam Ishaq Khan Institute, Pakistan. His past research has focused on Lead-free piezoelectric ceramics and currently studying different nanomaterials for hybrid supercapacitors applications. He is currently interested in perusing his PhD in the area of batteries and supercapacitors. After completion of the program, he aspires to work as a researcher in the industry.
Abstract:
The application of nontoxic Metal-Organic-Frameworks (MOFs) has recently obtained ground in batteries, hybrid supercapacitor and water splitting. Here, we prepared unprecedented Manganese based MOF (Trimesic acid used as linker) via hydrothermal approach to scrutinize their electrochemical properties. A three electrode setup was developed in which the Mn MOF revealed remarkable specific capacity of 1569.24 C g-1 at 3.6 A g-1 with long lasting capacity retention. Furthermore, a hybrid device was fabricated in such a way that the Mn MOF and activated carbon was functionalized as positive and negative electrodes, respectively. The constructed Mn MOF//AC device attained exceptional specific capacity, energy and power are 248.3 C/g, 60 Wh kg-1 and 2550 W kg-1, correspondingly. After 1000 galvanostatic cycles, the hybrid device results in outstanding cycling stability of 98.57% and coulombic efficiency of 96.97%. The nature of the device was validated through the Power’s law and Dunn’s model. Due to its electrochemical properties, Mn MOF//AC is a promising choice for battery-supercapacitor devices in portable electronics.
Victor Girard
University of Lorraine, France
Title: Spruce and beech sawmill waste as a source of nanolignin
Biography:
Victor Girard began his PhD in 2021 at the University of Lorraine within the LERMAB after obtaining an ENSTIB engineering degree specializing in biorefining. The theme of his research is the extraction and valorization of nanolignins by coupling organosolv process and steam explosion.
Abstract:
Wood processing produces large amount of residues such as barks, shavings, sawdust, chips. For instance, to produce 1 m3 of sawn timber, 1.7 to 2 m3 of log are required, generating nearly 50% of waste. The valorization of 1 m3 of a log by sawing produces then about 8-10% ok barks, 10-13% of sawdust and 20-30% of other wood chips (data for beech and spruce). Pulping and wood energy are the main outlet for these wastes, while many other valorization possibilities could be envisaged. Wood is a lignocellulosic material mainly composed of three polymeric fractions, cellulose, hemicellulose and lignin, which are highly entangled. As much as cellulose and hemicelluloses are well valorized today, lignin remains completely under-valued (thermal valorization). Thanks to its aromatic structure, lignin has many properties (biocide, antioxidant, UV-light blocker) which could be useful in technical applications. One of the ways of valorization of lignin still poorly explored is the production of nanolignins. Usually, the usefulness of nanoparticles lies in their size (<100 nm), which provides them a high surface reactivity as well as physic and chemical properties that the materials would not have at a macroscopic scale. Nanoparticles are nowadays intentionally incorporated in many consumer- products as for example sunscreens, toothpastes as well as in electronic devices and new medicinal treatments. The two goals of this work are to optimize a green extraction process of macrolignin from wood waste and then to optimize nanolignin production from lignin for a future valorization in both pharmaceutical and cosmetics applications.